Professor of Entomology

Department of Plant Protection

Head and Principal Investigator of the Beijing Key Laboratory for Pest Control and Sustainable Cultivation of Vegetables

Director General of the Institute of Vegetables and Flowers (IVF)

Chinese Academy of Agricultural Sciences (CAAS)

No. 12, Zhongguancun South Street, Haidian District, Beijing 100081; China

Personal Information:

Gender: Male

Born: July 1968 in Hunan Province, China

Tel: +86-10-62152945/82108798

Phone: +86-10-13311120738

Fax: +86-10-82109518

E-mail: zhangyoujun@caas.cn

Education:

1987-1991，B. S. Plant Protection, Hunan Agricultural University, Changsha, Hunan, China

1991-1996，Ph. D. Entomology, Chinese Agricultural University, Beijing, China

1999-2001，Postdoc Biochemistry, Institute for Chemical Research, Kyoto University, Kyoto, Japan

2013. 1-7，Senior Visiting Scholar, Department of Entomology, University of Kentucky, USA

Positions:

1996-1998，Assistant Professor，IVF, CAAS

1998-1999，Associate Professor，IVF, CAAS

2001-2005，Associate Professor，Head of the Entomological Research Group, IVF, CAAS

2005-Present，Professor，Head of the Entomological Research Group, IVF, CAAS

2013-Present，Principal Investigator，Head of the Beijing Key Laboratory for Pest Control and Sustainable Cultivation of Vegetables, IVF, CAAS

2014-2016，Director of the Department of Plant Protection, IVF, CAAS

2016-2018，Deputy Director General, IVF, CAAS

2019-Now，Director General, IVF, CAAS

Honors and Awards:

1.State Class Persons of National Talents, Engineering of Ministry of Personnel of China, 2009

2.National Science Fund for Distinguished Young Scholars, the National Natural Science Foundation of China, 2010

3.National Excellent Scholar of Science and Technology, China Association for Science and Technology, 2010

4.Special Government Allowances, the State Council of China, 2011

5.National Agricultural Technology Talents, Ministry of Agriculture of China, 2012

6.Qiushi Youth Award Prize, China Association for Science and Technology, 2012

7.Guanghua Engineering Prize of Science and Technology, Chinese Academy of Engineering, 2012

8.Mid-Youth Technology Innovation Leader, Ministry of Science and Technology of China, 2013

9.Technology Innovation Leader in the High-level Personnel Special Support Plan, the Organization Department of the Central Committee of the Communist Party of China, 2014

Professional Society Memberships:

1.Vice President/Secretary General, Chinese Society for Horticultural Science

2.Vice President, China Society of Plant Protection

2010-present

1.Editor In Chief，Horticultural Plant Journal

2.Associate Editor，Entomologia Generalis

3.Associate Editor，Pest Management Science

4.Associate Editor，Journal of Integrative Agriculture

5.Associate Editor，Frontiers in Physiology

6.Editorial Board Member，The Innovation Life

7.Editorial Board Member，Agriculture Communications

8.Editorial Board Member，Crop Health

Major Research Areas:

1.Whitefly (Bemisia tabaci)-virus-plant interactions, whitefly gut secondary symbionts, whitefly immune defense and defensive signaling, B/Q biotype whitefly competitive displacement mechanisms, whitefly distribution and resistance monitoring in China, molecular mechanisms of whitefly resistance to different insecticides, whitefly functional genomics, etc.

2.Molecular resistance mechanisms to Cry1Ac toxin from Bacillus thuringiensis (Bt) in diamondback moth (Plutella xylostella)

3.Traditional and novel Integrated Pest Management (IPM) strategies of major vegetable pests (RNAi or CRISPR/Cas9-based insect pest control strategy)

Grants Awarded (Principal Investigator, Selected)

1.Pest and Diseases Controlling Technology in Vegetable and Soybean, State Science and Technology Support Program of Ministry of Science and Technology, $800,000, 2006-2010

2.Diamondback moth resistance molecular detection and diagnostic technique with high-throughput sequencing method to some commonly used insecticides such as Bt toxin, fipronil etc., 863 Program of Ministry of Science and Technology, $80,000, 2007-2010

3.Cloning and functional analysis of target receptors of Bt toxin proteins, General Program of the National Natural Science Foundation of China, $50,000, 2009-2011

4.Monitoring and ecological impact mechanism of major invasive species in China, 973 Program of Ministry of Science and Technology, $360,000, 2009-2014

5.Molecular Mechanism of Host Induction Genetic Divergence by Bemisia tabaci, the National Science Fund for Distinguished Young Scholars, the National Natural Science Foundation of China (NSFC), $330,000, 2011-2014

6.Melon Pests Controlling Scientist of Melon Industry Technology System, Modern Agricultural Industry Technology System of Ministry of Agriculture, $570,000, 2011-2015

7.Integrative Controlling Technology and Demonstration in Crop Root Maggot Pests, Special Fund for Agro-Scientific Research in the Public Interest of Ministry of Agriculture, $3,860,000, 2013-2017

8.Integrative Genomic Analysis of Insecticide Resistance, the Driving Force for the Competitive Displacement of Sweetpotato Whitefly, Bemisia tabaci, in China, Key International Cooperation Program of the National Natural Science Foundation of China (NSFC), $450,000, 2015-2019

9.Dissection of the Genetic Networks Regulated by MAPK Signaling Pathway of Resistance to Bacillus thuringiensis Insecticidal Proteins in Plutella xylostella (L.), Key Program of the National Natural Science Foundation of China (NSFC), $500,000, 2017-2021

Publications (#Co-first author, *corresponding author)

1.Zhaojiang Guo#,*, Yang Bai#, Xinyi Zhang#, Le Guo#, Liuhong Zhu#, Dan Sun, Kaiyue Sun, Xudan Xu, Xin Yang, Wen Xie, Shaoli Wang, Qingjun Wu, Neil Crickmore, Xuguo Zhou, Youjun Zhang*. RNA m6A methylation suppresses insect juvenile hormone degradation to minimize fitness costs in response to a pathogenic attack. Advanced Science, 2024, 11(6): 2307650.

2.Cheng Gong#, Zhaojiang Guo#, Yuan Hu#, Zezhong Yang#, Jixing Xia, Xin Yang, Wen Xie, Shaoli Wang, Qingjun Wu, Wenfeng Ye, Xuguo Zhou, Ted C. J. Turlings*, Youjun Zhang*. A horizontally transferred plant fatty acid desaturase gene steers whitefly reproduction. Advanced Science, 2024, 11(10): 2306653.

3.Zezhong Yang#, Zhaojiang Guo#, Cheng Gong#, Jixing Xia#, Yuan Hu, Jie Zhong, Xin Yang, Wen Xie, Shaoli Wang, Qingjun Wu, Wenfeng Ye, Baiming Liu, Xuguo Zhou, Ted C. J. Turlings*, Youjun Zhang*. Two horizontally acquired bacterial genes steer the exceptionally efficient and flexible nitrogenous waste cycling in whiteflies. Science Advances, 2024, 10(5): eadi3105.

4.Zhaojiang Guo#,*, Le Guo#, Yang Bai#, Shi Kang, Dan Sun, Jianying Qin, Fan Ye, Shaoli Wang, Qingjun Wu, Wen Xie, Xin Yang, Neil Crickmore, Xuguo Zhou, Youjun Zhang*. Retrotransposon-mediated evolutionary rewiring of a pathogen response orchestrates a resistance phenotype in an insect host. PNAS, 2023, 120(14): e2300439120.

5.Zhaojiang Guo#,*, Le Guo#, Jianying Qin#, Fan Ye#, Dan Sun#, Qingjun Wu, Shaoli Wang, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Youjun Zhang*. A single transcription factor facilitates an insect host combating Bacillus thuringiensis infection while maintaining fitness. Nature Communications, 2022, 13(1): 6024..

6.Le Guo#, Zhouqiang Cheng#, Jianying Qin#, Dan Sun#, Shaoli Wang, Qingjun Wu, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Zhaojiang Guo*, Youjun Zhang*. MAPK-mediated transcription factor GATAd contributes to Cry1Ac resistance in diamondback moth by reducing PxmALP expression. PLoS Genetics, 2022, 18(2): e1010037.

7.Dan Sun#, Liuhong Zhu#, Le Guo#, Shaoli Wang, Qingjun Wu, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Zhaojiang Guo*, Youjun Zhang*. A versatile contribution of both aminopeptidases N and ABC transporters to Bt Cry1Ac toxicity in the diamondback moth. BMC Biology, 2022, 20(1): 33.

8.Zhaojiang Guo#,*, Shi Kang#, Qingjun Wu, Shaoli Wang, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Youjun Zhang*. The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host. PLoS Pathogens, 2021, 17(9): e1009917.

9.Xin Yang#, Xuegao Wei#, Jing Yang#, Tianhua Du, Cheng Yin, Buli Fu, Mingjiao Huang, Jingjing Liang, Peipan Gong, Shaonan Liu, Wen Xie, Zhaojiang Guo, Shaoli Wang, Qingjun Wu, Ralf Nauen, Xuguo Zhou, Chris Bass*, Youjun Zhang*. Epitranscriptomic regulation of insecticide resistance. Science Advances, 2021, 7(19): eabe5903.

10.Jixing Xia#, Zhaojiang Guo#, Zezhong Yang#, Haolin Han, Shaoli Wang, Haifeng Xu, Xin Yang, Fengshan Yang, Qingjun Wu, Wen Xie, Xuguo Zhou, Wannes Dermauw, Ted C. J. Turlings*, Youjun Zhang*. Whitefly hijacks a plant detoxification gene that neutralizes plant toxins. Cell, 2021, 184(7), 1693–1705.

11.Zhaojiang Guo#,*, Shi Kang#, Dan Sun#, Lijun Gong, Junlei Zhou, Jianying Qin, Le Guo, Liuhong Zhu, Yang Bai, Fan Ye, Qingjun Wu, Shaoli Wang, Neil Crickmore, Xuguo Zhou, Youjun Zhang*. MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host. Nature Communications, 2020, 11(1): 3003.

12.Xin Yang, Shun Deng, Xuegao Wei, Jing Yang, Qiannan Zhao, Cheng Yin, Tianhua Du, Zhaojiang Guo, Jixing Xia, Zezhong Yang, Wen Xie, Shaoli Wang, Qingjun Wu, Fengshan Yang, Xuguo Zhou, Ralf Nauen, Chris Bass*, Youjun Zhang*. MAPK-directed activation of the whitefly transcription factor CREB leads to P450-mediated imidacloprid resistance. PNAS, 2020, 117(19): 10246–10253.

13.Zhaojiang Guo#, Shi Kang#, Defeng Chen#, Qingjun Wu, Shaoli Wang, Wen Xie, Xun Zhu, Simon W. Baxter, Xuguo Zhou, Juan Luis Jurat-Fuentes*, Youjun Zhang*. MAPK signaling pathway alters expression of midgut ALP and ABCC genes and causes resistance to Bacillus thuringiensis Cry1Ac toxin in diamondback moth. PLoS Genetics, 2015, 11(4): e1005124.